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UP 614-04 → 2-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | UP 614-04 | HCID 134375 | — |
| 反応物 | Maleic Acid | HCID 444266 | — |
| 反応物 | 4-Benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine | HCID 70601820 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate | HCID 86736083 | — |
反応手順
18 g of 4-benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, 15 g of an oily product are obtained and are dissolved in hot isopropyl alcohol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly. 16.5 g of 2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate are obtained, m.p. 200° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152434 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-407ff9eee7264ce1a915aedfde839f02 |
| 出典メモ | uspto-grants-1979_05 |