Hydrochloric Acid → 1,6-Dihydro-4-hydroxy-1-methyl-2-methoxy-6-oxo-pyrimidine
反応式
[OH:1][C:2]1[N:3]=[C:4](SC)[N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1.[CH3:12][OH:13].Cl>CCOCC>[OH:1][C:2]1[N:3]=[C:4]([O:13][CH3:12])[N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1参加物
5
実験手順
A mixture of 172 g (1 mol) of 1,6-dihydro-4-hydroxy-1-methyl-2-methylthio-6-oxo-pyrimidine, 700 ml of methanol and 5 ml of a solution of hydrogen chloride in ether was boiled for 10 days under reflux. The reaction mixture was then filtered while still hot and the filtrate is evaporated in vacuo. The residue was triturated with ether and the crystalline product was filtered off. In this way, 71 g (40% of theory) of 1,6-dihydro-4-hydroxy-1-methyl-2-methoxy-6-oxo-pyrimidine were obtained in the form of colorless crystals of melting point 170°-171° C. ##STR11##
後処理
- temperatureunder reflux
- filtrationThe reaction mixture was then filtered while still hot and the filtrate
- customis evaporated in vacuo
- customThe residue was triturated with ether
- filtrationthe crystalline product was filtered off
出典と根拠
- ORDレコード
- ord-be41bb75b42b464f9fa7713bb4e877ed
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04152426
反応ノート
読み込み中…