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Hydrazoic acid → HCID 178420316、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazoic acid | HCID 24530 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 1-benzyl-1H-imidazole-2-carbaldehyde | HCID 139082 | — |
| 反応物 | 1H-Imidazole-2-carbonitrile, 1-(phenylmethyl)- | HCID 11030475 | — |
| 反応物 | HCID 178418441 | HCID 178418441 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178420316 | HCID 178420316 | — |
反応手順
Obtained by reacting 9.3 g (0.05 mol) of 1-benzyl-2-formylimidazole (see Liebigs Ann. Chem. 718 (1968) pp. 249-259) with 8.0 g (0.15 mol) of ammonium chloride and 9.8 g (0.15 mol) of sodium azide in 50 ml of dimethylformamide at 120°-130° C. The isolation of the 1-benzyl-2-cyanoimidazole intermediate (obtained by Schmidt-rearrangement) may be omitted, since this compound adds excess hydrazoic acid to the tetrazole in situ. After 20 hours, it is cooled, and 500 ml of water are added, the precipitate formed filtered off and recrystallised several times from dimethylformamide. M.p. 274°-275° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152440 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-faced8bfa88b4593be37b6ecae11b106 |
| 出典メモ | uspto-grants-1979_05 |