Ammonia → (4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261931

反応式

HRID 261931 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:10]2[N:11](S(C3C=CC(C)=CC=3)(=O)=O)[CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Cl.N>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:10]2[NH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 11838798alpha-(p-Bromophenyl)-alpha-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol

生成物 1

HCID 12433864(4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 24.8 g. (0.052 mol) of α-(p-bromophenyl)-α-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol, 160 ml. of 2 N hydrochloric acid solution (0.156 mol) and about 500 ml. of water was boiled under reflux for 5 hours. After cooling the mixture was made alkaline by addition of ammonia. The precipitated solid was collected, treated with activated carbon in boiling toluene and crystallised from toluene. Melting point of the product was 156°-158° C.

後処理

  1. additionA mixture of 24.8 g
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling the mixture
  4. customThe precipitated solid was collected
  5. additiontreated with activated carbon
  6. customcrystallised from toluene
  7. customwas 156°-158° C.

出典と根拠

ORDレコード
ord-26d17c2475ad44a4a697a698d7e18002
出典データセット
uspto-grants-1979_05
特許番号
US04152441

関連ノート

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