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Acetic Acid → (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-[(Benzyloxy)methyl]-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol | HCID 12433915 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol | HCID 12433863 | — |
反応手順
About 17 g. (0.042 mol) of 1-[(benzyloxy)methyl]-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was boiled under reflux in a mixture of 85 ml. of glacial acetic acid, 8.5 ml. of water and 8.5 ml. of concentrated hydrochloric acid solution. Acetic acid was removed by evaporation and the base was liberated by addition of 2 N sodium hydroxide solution. It was crystallised from isopropyl alcohol. Melting point of the product was 162°-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152441 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-cceeaee25d9846e69e81e02792f0e7c9 |
| 出典メモ | uspto-grants-1979_05 |