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Picric Acid → 1-Allyl-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Picric Acid | HCID 6954 | — |
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol | HCID 12433863 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-Allyl-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol | HCID 12433929 | — |
反応手順
A mixture of 3.4 g (0.028 mol) of freshly distilled allyl bromide, 7 g (0.025 mol) of α-(p-chlorophenyl)-α-phenylimidazole-2-methanol (prepared according to Example IV), 1.2 g (0.030 mol) of sodium hydroxide, 0.050 g of picric acid and 50 ml. of acetonitrile was refluxed for 5 hours. The warm reaction mixture was filtered and water was added to the filtrate. The precipitate formed was filtered off, washed with water and petroleum ether (boiling range 40°-60° C.) and three times crystallised from isopropyl alcohol. 1-Allyl-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was obtained. Melting point 165°-165.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152441 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-9019765763da459a8ba96ec7d4673355 |
| 出典メモ | uspto-grants-1979_05 |