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Water → alpha-(p-Chlorophenyl)-1-methyl-alpha-phenylimidazole-2-methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Methylimidazole | HCID 1390 | — |
| 反応物 | 4-Chlorobenzophenone | HCID 8653 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | alpha-(p-Chlorophenyl)-1-methyl-alpha-phenylimidazole-2-methanol | HCID 12801655 | — |
反応手順
A solution of 25.5 g (0.08 mol) of 20% butyl lithium in n-hexane in 50 ml. of anhydrous diethyl ether was added at room temperature to a solution of 5 g (0.06 mol) of 1-methylimidazole in 50 ml. of anhydrous diethyl ether. The reaction mixture was stirred for one hour and then a solution of 15.6 g (0.07 mol) of 4-chlorobenzophenone in diethyl ether was added dropwise. The reaction mixture was stirred for 3 hours and it was then poured into a mixture of ice and water. The solid matter was filtered off and crystallised from ethanol. α-(p-Chlorophenyl)-1-methyl-α-phenylimidazole-2-methanol was obtained. Melting point 185°-186° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04152441 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-59a2ee3cb0234a98bb9b3248b79eefed |
| 出典メモ | uspto-grants-1979_05 |