rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride → cis-2-Cyclohexylcyclopentylamine hydrochloride

HRID 261996

反応式

HRID 261996 の反応式
[ClH:1].[C:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>O>[ClH:1].[CH:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 70051154rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochlorideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 70050481cis-2-Cyclohexylcyclopentylamine hydrochloride収率 33.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Using rhodium-on-charcoal catalyst in a Paar shaker, 12.6 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 204°-206° C. in 100 ml of water was hydrogenated. In 20 hours when the theoretical amount of hydrogen had been taken up the catalyst was removed by filtration, the filtrate made basic with sodium hydroxide solution, and the resulting precipitate was extracted into ether. After evaporation of the ether the residue was distilled, B.P. 100°-102° C. (6.0 mm). The hydrochloride salt was prepared and recrystallized from isopropanolether to give 4.4 g of cis-2-(cyclohexyl)cyclopentylamine hydrochloride, M.P. 174°-176° C.

後処理

  1. customthe catalyst was removed by filtration
  2. extractionthe resulting precipitate was extracted into ether
  3. customAfter evaporation of the ether the residue
  4. distillationwas distilled
  5. customrecrystallized from isopropanolether

出典と根拠

ORDレコード
ord-4faf5b9c58494fa0b2cabdeda263308e
出典データセット
uspto-grants-1979_05
特許番号
US04153235

関連ノート

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