O-Xylene → N-Methylenepyrrolidonyl-2-Cyclopentoxyaniline

HRID 262014

反応式

HRID 262014 の反応式
[CH:1]1([O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[NH2:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.C([N:16]1[CH2:20][CH2:19][CH2:18][C:17]1=[O:21])O.[C:22]1(C)C(C)=CC=CC=1>O>[CH2:22]=[N:9][C:8]1[CH:10]=[CH:11][CH:12]=[C:13]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[C:7]=1[O:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 7237O-XyleneHCID 849112-Pyrrolidinone, 1-(hydroxymethyl)-HCID 64853982-(Cyclopentyloxy)aniline

生成物 1

HCID 70609772N-Methylenepyrrolidonyl-2-Cyclopentoxyaniline収率 51.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Cyclopentoxyaniline (10.0 g, 0.057 mole), N-methylolpyrrolidone (9.75 g, 0.85 mole) and xylene (25 cc) were refluxed under azeotropic conditions with the removal of 1.5 cc of water. The xylene was removed by rotary evaporation and the product was crystallized from 100 cc of hexane to yield 8.0 g (51.6%) of product, m.p. 87°-87.5° C.

後処理

  1. customThe xylene was removed by rotary evaporation
  2. customthe product was crystallized from 100 cc of hexane

出典と根拠

ORDレコード
ord-620428e63c7243ba8d19feeb5620722f
出典データセット
uspto-grants-1979_05
特許番号
US04153446

関連ノート

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