化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-Chlorophenyl Isocyanate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | 4-Chlorophenylurea | HCID 8796 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 触媒 | Tetrabutylammonium Tetrafluoroborate | HCID 67932 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
反応手順
4-Chlorophenyl urea (8.5 parts) and a solution of sodium nitrite (6.9 parts) in water (10 parts) were added over 6 hours to a mixture of conc. hydrochloric acid (10.3 parts) chloroform (130 parts) and tetra-n-butyl ammonium fluoroborate (10% by weight based on 4-chlorophenyl urea) at -10° to -5° C. The mixture was stirred for a further 15 minutes then the stirrer stopped and layers allowed to separate. No solid was present at this stage. 5 mls of the organic layer was taken for analysis and the remainder kept cold until required.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04153624 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-b62cc6b7e3f94970b45c84cfc794cd41 |
| 出典メモ | uspto-grants-1979_05 |