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Benzene, 1-bromo-3-(trifluoromethyl)- → 2,2-Dimethyl-4-(3-trifluoromethylphenyl)-2H-chromene-7-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one | HCID 600902 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2,2-Dimethyl-4-(3-trifluoromethylphenyl)-2H-chromene-7-ol | HCID 12071757 | 86.2% |
反応手順
3-Bromobenzotrifluoride (61 g) in dry ether (100 ml) was added to magnesium (6.6 g) in ether (50 ml). 2,2-Dimethylchroman-4-one-7-ol (17.4 g) suspended in ether (500 ml) was added and the mixture refluxed for 16 hourss. The reaction mixture was poured into ammonium chloride solution and extracted with ether. The combined ether layers were washed with 2 N HCl (2×100 ml) and dried (MgSO4). Removal of the solvent under reduced pressure gave the title compound (25 g), m.p. 102°-106° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04153617 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-38c1fdbfa4fd41cebf2cc7138c084fcc |
| 出典メモ | uspto-grants-1979_05 |