2-(3-Phthalimidopropylthio)oxazole → 2-(3-Aminopropyl)thiooxazole
反応式
[H-].NN.C1(=O)[N:8]([CH2:9][CH2:10][CH2:11][S:12][C:13]2[O:14][CH:15]=[CH:16][N:17]=2)C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][S:12][C:13]1[O:14][CH:15]=[CH:16][N:17]=1参加物
4
実験手順
Hydrazine hydride (5.3 g) was added carefully to a solution of 2-(3-phthalimidopropylthio)oxazole (10 g) in ethanol (173 ml) with stirring. The solution was then heated under reflux for 25 minutes. After cooling, and filtration from phthalhydrazide, the filtrate was concentrated under reduced pressure and the residue was re-evaporated with ethanol to yield crude 2-(3-aminopropylthio)oxazole.
後処理
- temperatureThe solution was then heated
- temperatureunder reflux for 25 minutes
- temperatureAfter cooling
- filtrationfiltration from phthalhydrazide
- concentrationthe filtrate was concentrated under reduced pressure
- customthe residue was re-evaporated with ethanol
出典と根拠
- ORDレコード
- ord-26eddb0c10434473bd309a13d818dcce
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04153704
反応ノート
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