Triethylamine → 3-Bromo-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)propan-1-one

HRID 262295ノート

反応式

HRID 262295 の反応式
[Br:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[C:7]1([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][CH2:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C>C1C=CC=CC=1>[Br:1][CH2:2][CH2:3][C:4]([N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:13]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:14]1)=[O:5]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 84944Propanoyl chloride, 3-bromo-HCID 109323533-phenyl-2,3-dihydro-1H-indole

生成物 1

HCID 213204593-Bromo-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)propan-1-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
10 °C

実験手順

A solution of 9.1 ml of 3-bromopropionylchloride in 10 ml of dry benzene was added dropwise to a solution of 10.0 g of 3-phenylindoline and 10 ml of triethylamine in 100 ml of dry benzene cooled to 10° C. The precipitated triethylamine hydrochloride was separated by filtration, the benzene was removed from the filtrate in vacuo at room temperature and the residue recrystallized from ethanol to give 5.6 g of the desired N-(3-bromopropionyl)-3-phenylindoline having a melting point of 98°-9° C.

後処理

  1. customThe precipitated triethylamine hydrochloride was separated by filtration
  2. customthe benzene was removed from the filtrate in vacuo at room temperature
  3. customthe residue recrystallized from ethanol

出典と根拠

ORDレコード
ord-f8eb417eb50d445cbd2f5e7abb475f60
出典データセット
uspto-grants-1979_05
特許番号
US04153789

反応ノート

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