Potassio isocyanate → 3-Phenyl-2,3-dihydro-1H-indole-1-carboxamide

HRID 262301

反応式

HRID 262301 の反応式
Cl.[C:2]1([CH:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:17]=[C:18]=[O:19].[K+]>O.C(O)C>[C:18]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9]1)(=[O:19])[NH2:17]

参加物

5

反応物 2

HCID 11051572Potassio isocyanateHCID 213204633-Phenyl-2,3-dihydro-1H-indole--hydrogen chloride (1/1)

生成物 1

HCID 538455683-Phenyl-2,3-dihydro-1H-indole-1-carboxamide

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture comprising 2.3 g of 3-phenyl indoline hydrochloride in 23 ml of water and 0.81 g of potassium isocyanate in 23 ml of ethanol was stirred for 15 minutes at room temperature. The precipitate which resulted was filtered off, washed with water and recrystallized from dilute ethanol. The yield of N-carbamoyl-3-phenylindoline was 0.9 g and the product had a melting point of 144°-145° C.

後処理

  1. customThe precipitate which resulted
  2. filtrationwas filtered off
  3. washwashed with water
  4. customrecrystallized from dilute ethanol

出典と根拠

ORDレコード
ord-a26935f1678c4ebe8890882cefa5be19
出典データセット
uspto-grants-1979_05
特許番号
US04153789

関連ノート

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