2-(Diisopropylamino)ethyl chloride → alpha-[2-(Diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)-alpha-(2-pyridyl)acetonitrile

HRID 262321ノート

反応式

HRID 262321 の反応式
[CH:1]([N:4]([CH:16]([CH3:18])[CH3:17])[CH2:5][CH2:6][CH:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)[C:8]#[N:9])([CH3:3])[CH3:2].Cl[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.C(N(C(C)C)CCC(C1C=CC=CC=1)C#N)(C)C.ClCCN(C(C)C)C(C)C>>[CH:16]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][C:7]([CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)[C:8]#[N:9])([CH3:18])[CH3:17]

参加物

5

反応物 4

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 748271-(2-Chloroethyl)piperidineHCID 126122104-Diisopropylamino-2-phenyl-butyronitrileHCID 133196744-Diisopropylamino 2-(2-pyridyl)butyronitrile

生成物 1

HCID 21320527alpha-[2-(Diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)-alpha-(2-pyridyl)acetonitrile

実験手順

Substitution of equivalent quantities of α-[2-(diisopropylamino)ethyl]-α-(2-pyridyl)acetonitrile and 1-(2-chloroethyl)piperidine for α-[2-(diisopropylamino)ethyl]-α-phenylacetonitrile and 2-chloro-N,N-diisopropylethylamine called for respectively in the procedure of Example 2, Method B affords α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)-α-(2-pyridyl)acetonitrile, as an oil boiling at about 160°-170° C. at 0.5-0.7 mm. pressure.

出典と根拠

ORDレコード
ord-032e891ed1cb4200a7a8e53af8d9f620
出典データセット
uspto-grants-1979_05
特許番号
US04153797

反応ノート

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