N-ethyl-2-methoxyaniline → 7-Methoxy-1,2-dihydroisoquinolin-1-one

反応式

C[N:2]1[C:11](CCC2C=CC(OCC3OC3)=C(OC)C=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:27][CH3:28])=[CH:7][CH:8]=2)[C:3]1=[O:29].COC1C=CC=CC=1NCC>>[CH3:28][O:27][C:6]1[CH:5]=[C:4]2[C:9]([CH:10]=[CH:11][NH:2][C:3]2=[O:29])=[CH:8][CH:7]=1

参加物

反応物 2

HCID 10888090N-ethyl-2-methoxyaniline

HCID 21319052HCID 21319052、化合物

生成物 1

HCID 126435307-Methoxy-1,2-dihydroisoquinolin-1-one収率 74%

実験手順

2-Methyl-3-[3-methoxy-4-(3-(2-o-methoxy-phenyl-ethyl-amino)-2-hydroxy)-propoxy)-phenethyl]-7-methoxy-isoquinolin-1(2H)-one was prepared analogous to Example 2 from 2-methyl-3-[3-methoxy-4-(2,3-epoxypropoxy)-phenethyl]-7-methoxy-isoquinolin-1(2H)-one and 2-methoxyphenyl-ethylamine.

出典と根拠

ORDレコード: ord-1949de563a9944399e1b98765cd3f0ba
出典データセット: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04154837

反応ノート

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