化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → trans-p-Cyano-N-[2-(dimethylamino)cyclohexyl]-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Cyanobenzoyl chloride | HCID 80172 | — |
| 反応物 | (1R,2R)-N1,N1-Dimethylcyclohexane-1,2-diamine | HCID 11275066 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | trans-p-Cyano-N-[2-(dimethylamino)cyclohexyl]-benzamide | HCID 53649711 | 63% |
反応手順
The titled amide was prepared according to general procedure B using p-cyanobenzoyl chloride (1.65 g.; 0.01 mole), the trans-2-(dimethylamino)cyclohexylamine (1.42 g.; 0.01 mole) and triethylamine (1.01 g.; 0.01 mole) but using CH2Cl2 for extraction. The crude solid was crystallized from ether to give colorless needles, 1.71 g. (63% yield), m.p. 160°-161°. uv λmax 236 nm (ε 17,900); sh 285 (2,550). ir NH 3320; N-alkyl 2780; C=N 2220; C=O 1635; C=C 1610, 1500; amide II 1550; aromatic 860. NMR in CDCl3 (60 MHz) was in accord. Mass spectrum M+ 271.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04148914 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-32950554ecca44488d74a21be65e7625 |
| 出典メモ | uspto-grants-1979_04 |