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Benzoyl chloride, 3-chloro- → trans-m-Chloro-N-[2-(dimethylamino)cyclohexyl]-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride, 3-chloro- | HCID 69252 | — |
| 反応物 | N1,N1-dimethylcyclohexane-1,2-diamine | HCID 12447266 | — |
| 生成物 | trans-m-Chloro-N-[2-(dimethylamino)cyclohexyl]-benzamide | HCID 53979363 | 62% |
反応手順
This titled amide was prepared by general procedure B from 2-(dimethylamino)cyclohexylamine and 3-chlorobenzoyl chloride. The crude product was crystallized from ether-petroleum ether (30°-60°); yield 62%, m.p. 112°-113°. The analytical sample melted at 112.5°-113.5°. uv sh 217 nm (ε 11,850); sh 226 (9,550); sh 277 (1,200); sh 287 (623). ir NH/=CH 3320, 3070; N-alkyl 2760; C=O 1635; C=C 1595, 1570; amide II 1545. NMR in CDCl3 (100 MHz) was in accord. Mass spectrum M+ 280.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04148914 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-d0dbd12366db44bc83e7eca24f2329b6 |
| 出典メモ | uspto-grants-1979_04 |