Diazomethane → 1-[3-(ethyldithio)-2-methylpropanoyl]-L-proline methyl ester

反応式

[SH:1][CH2:2][CH:3]([CH3:14])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].[SH:15][CH2:16][CH2:17]C(N1CCC[C@H]1C(O)=O)=O.[N+](=[CH2:30])=[N-]>>[CH3:30][O:9][C:8](=[O:10])[C@@H:7]1[CH2:11][CH2:12][CH2:13][N:6]1[C:4](=[O:5])[CH:3]([CH3:14])[CH2:2][S:1][S:15][CH2:16][CH3:17]

参加物

反応物 3

HCID 9550Diazomethane

HCID 999781-(3-Mercapto-1-oxopropyl)-L-proline

HCID 128775471-(2-Methyl-3-sulfanylpropanoyl)-L-proline

生成物 1

HCID 539351991-[3-(ethyldithio)-2-methylpropanoyl]-L-proline methyl ester

実験手順

By substituting 1-(3-mercapto-2-methylpropanoyl)-L-proline for the 3-mercaptopropanoyl-L-proline in the procedure of Example 97 and then treating the product with ethereal diazomethane as in the procedure of Example 72, 1-[3-(ethyldithio)-2-methylpropanoyl]-L-proline methyl ester is obtained.

出典と根拠

ORDレコード: ord-ffc2798906cf4c7cbb1bad26be891fb4
出典データセット: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04154840

反応ノート

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