CH2N2Pb → HCID 178484967、化合物

HRID 262601ノート

反応式

HRID 262601 の反応式
[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])=S.[N:17]#[C:18][NH2:19].[Pb]>>[C:18]([NH:19][C:3]([NH:2][CH3:1])=[N:5][CH2:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])#[N:17]

参加物

3

反応物 2

HCID 22262466CH2N2PbHCID 178486113HCID 178486113、化合物

生成物 1

HCID 178484967HCID 178484967、化合物収率 15%

実験手順

The reaction of N-methyl-N'-[3-((4-methyl-5-imidazolyl)methylthio)propyl]thiourea (5.9 g.) with lead cyanamide (17.5 g.) by a procedure similar to that described in Example 3(b) afforded N-cyano-N'-methyl-N"-[ 3-((4-methyl-5-imidazolyl)methylthio)propyl]guanidine (0.91 g.), m.p. 156°-158°, following chromatography on silica gel with successive elution by chloroform-ethyl acetate (1:1), ethyl acetate and ethyl acetate isopropyl alcohol (5:1) and final recrystallisation from isopropyl alcohol-ether. (Found: C, 49.5; H, 7.0; S, 12.0. C11H18N6S requires: C, 49.6; H, 6.8; S12.0).

出典と根拠

ORDレコード
ord-36ee3aec1ef04db3ab0f1d0e97357f88
出典データセット
uspto-grants-1979_05
特許番号
US04154844

反応ノート

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