Methylamine → N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

HRID 262653ノート

反応式

HRID 262653 の反応式
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[CH:16]=[CH:15][S:14][N:13]=1)SC)#[N:2].[CH3:17][NH2:18]>>[C:1]([NH:3][C:4]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[CH:16]=[CH:15][S:14][N:13]=1)=[N:18][CH3:17])#[N:2]

参加物

3

反応物 2

HCID 6329MethylamineHCID 20567647N-cyano-N'-[2-(3isothiazolylmethylthio)ethyl]-S-methylisothiourea

生成物 1

HCID 9992541N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

実験手順

The reaction of N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-S-methylisothiourea (0.27 g.) with excess methylamine according to the procedure described in Example 3(c) and recrystallization of the product from isopropyl acetate afforded N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine (0.12 g.), m.p. 91°-93° (Found: C, 42.4; H, 5.1; N, 27.3; S, 25.2. C9H13N5S2 requires: C, 42.3; H, 5.1; N, 27.4; S, 25.1).

後処理

  1. customdescribed in Example 3(c) and recrystallization of the product from isopropyl acetate

出典と根拠

ORDレコード
ord-c6b2cb5733174896a9d9972b96bd59d6
出典データセット
uspto-grants-1979_05
特許番号
US04154844

反応ノート

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