Trifluoroalanine → 2-Bromo-3,3,3-trifluoropropanoic acid
反応式
[F:1][C:2]([F:9])([F:8])[C@@H:3]([C:5]([OH:7])=[O:6])N.N([O-])=O.[Na+].[Br-:14].[K+]>S(=O)(=O)(O)O>[Br:14][CH:3]([C:2]([F:9])([F:8])[F:1])[C:5]([OH:7])=[O:6]参加物
5
実験手順
3,3,3-Trifluoroalanine (88 g.) is dissolved in a mixture of potassium bromide (250 g.) and 2.5 N sulfuric acid (1.240 ml.). The solution is chilled to 0° with an ice-salt bath and sodium nitrite (65.5 g.) is added in small portions over a one hour period with vigorous stirring. The reaction mixture is stirred in the cooling bath for another hour and then extracted with ether. The organic layer is washed with water, dried over magnesium sulfate and concentrated to dryness in vacuo to yield 2-bromo-3,3,3-trifluoropropanoic acid.
後処理
- temperatureThe solution is chilled to 0° with an ice-salt bath
- extractionextracted with ether
- washThe organic layer is washed with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated to dryness in vacuo
出典と根拠
- ORDレコード
- ord-a2c58975a8c041c69d9ea80352ea96ec
- 出典データセット
- uspto-grants-1979_05
- 特許番号
- US04154935
反応ノート
読み込み中…