Ammonia → 1-(2-carbamoylpropanoyl)-L-proline

反応式

C([O:3][C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])=O)C.[NH3:18]>>[C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[NH2:18]

参加物

反応物 2

HCID 222Ammonia

HCID 536785471-(2-ethoxycarbonylpropanoyl)-L-proline

生成物 1

HCID 542390101-(2-carbamoylpropanoyl)-L-proline

実験手順

1-(2-Ethoxycarbonylpropanoyl)-L-proline (2 g.) is dissolved in 10% methanolic ammonia and the mixture stored at room temperature in a pressure flask. When thin layer chromatographic analysis indicates that all the starting material has been converted to the amide, the mixture is concentrated to dryness, and the residual ammonium salt is converted to the free acid with ion exchange resin (Dowex 50 hydrogen form) to obtain 1-(2-carbamoylpropanoyl)-L-proline, yield 1.1 g.

後処理

customthe mixture stored at room temperature in a pressure flask
concentrationthe mixture is concentrated to dryness

出典と根拠

ORDレコード: ord-6c84b9daaa364e16a07696448c258adb
出典データセット: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04154937

反応ノート

読み込み中…

参加物