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Methane → Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methane | HCID 297 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | Ethyl bromoacetylglyoxylate | HCID 13455954 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate | HCID 4356513 | — |
反応手順
195 g of ethyl bromoacetylglyoxylate are added dropwise to a solution of 66 g of thiourea in 450 ml of water and 450 ml of ethanol at 5° and after the addition has ended, the mixture is stirred at room temperature for 30 minutes and at 50° for 30 minutes and, after adding active charcoal, the resulting reaction mixture is then filtered. The filtrate is brought to pH 7 by adding sodium bicarbonate solution, whereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE035754 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3c1efdc8bce441deb9547de62f031a43 |
| 出典メモ | uspto-grants-1998_03 |