Potassium Carbonate → HCID 54199046、化合物

HRID 263028

反応式

HRID 263028 の反応式
C(=O)([O-])[O-].[K+].[K+].[P:7](Cl)([O:11][CH3:12])([O:9][CH3:10])=[S:8].[C:14]([C:16]1[S:17][C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:19][C:20]=1[OH:21])#[N:15]>CC(C)=O>[C:14]([C:16]1[S:17][C:18]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:19][C:20]=1[O:21][P:7]([O:11][CH3:12])([O:9][CH3:10])=[S:8])#[N:15]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 17304Dimethyl phosphorochloridothionateHCID 21317938HCID 21317938、化合物

生成物 1

HCID 54199046HCID 54199046、化合物収率 79%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
20 °C

実験手順

7 g of potassium carbonate and 8 g of O,O-dimethyl chlorothiophosphate were added to a solution of 10.5 g of 2-cyano-3-hydroxy-5-phenyl-thiophene in 120 ml of acetone and the mixture was stirred at 20° C. for 15 hours and was then filtered. The filtrate was evaporated to dryness and the crystal residue was empasted with petroleum ether. The crystals were then crystallized from isopropyl ether to obtain 12.8 g of 2-cyano-3-(dimethoxythiophosphoryloxy)-5-phenylthiophene melting at 95° C.

後処理

  1. filtrationwas then filtered
  2. customThe filtrate was evaporated to dryness
  3. customThe crystals were then crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-6fe98b1acfe84105b8a74768c904c7d5
出典データセット
uspto-grants-1979_05
特許番号
US04155996

関連ノート

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