関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | O,O-diethyl phosphorochloridothioate | HCID 17305 | — |
| 反応物 | 5-Butoxy-3-hydroxythiophene-2-carbonitrile | HCID 21317900 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Cyano-3-(diethoxythiophosphoryloxy)-5-n-butoxy-thiophene | HCID 54416426 | 80.6% |
反応手順
7 g of potassium carbonate and 9.4 g of O,O-diethyl chlorothiophosphate were added to a solution of 9.8 g of 2-cyano-3-hydroxy-5-n-butoxy-thiophene in 150 ml of acetonitrile and the mixture was stirred for 24 hours at 20° C. and was filtered. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with benzene yielded 14 g of 2-cyano-3-(diethoxythiophosphoryloxy)-5-n-butoxy-thiophene with a refractive index of nD20 =1.525.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04155996 |
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| 出典データセット | uspto-grants-1979_05 |
|---|
| ORD ID | ord-50c477b0f52c4dcbb3707af80acb45b0 |
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| 出典メモ | uspto-grants-1979_05 |
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