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Water → 1-Methyl-3(carboethoxypropyl)-7-(pivaloyloxymethyl)xanthine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Ethyl 4-iodobutanoate | HCID 10890062 | — |
| 反応物 | 1-Methyl-7-(pivaloyloxymethyl)xanthine | HCID 12879841 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Chloroform ethanol | HCID 21889567 | — |
| 生成物 | 1-Methyl-3(carboethoxypropyl)-7-(pivaloyloxymethyl)xanthine | HCID 12879842 | 123.6% |
反応手順
A mixture of 1-methyl-7-(pivaloyloxymethyl)xanthine (350 mg, 1.25 mmes) sodium carbonate (265 mg, 2.50 mmoles) and ethyl 4-iodobutyrate (384 μl, 2.50 mmole) in 5.8 ml dry DMF was stirred under nitrogen at room temperature for 18 hours. Water was added and the reaction mixture extracted with chloroform. After drying, the extracts were stripped to leave a yellow oil which goes to chromotographed on four thick silica gel plates with 10% EtOH/CHCl3. The band was scraped off and eluted with 100 ml of 25% EtOH/CHCl3 to yield 609 mg of the desired product as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04156081 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-6d48475f834d47b1a6bcd738463e1005 |
| 出典メモ | uspto-grants-1979_05 |