関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Ethyl 2-bromovalerate | HCID 79071 | — |
| 反応物 | Phthalimide potassium salt | HCID 24194345 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl alpha-phthalimidopentanoate | HCID 13791337 | — |
反応手順
To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04148998 |
|---|
| 出典データセット | uspto-grants-1979_04 |
|---|
| ORD ID | ord-238e2c7868bf4c0ab667f4ccfcc35579 |
|---|
| 出典メモ | uspto-grants-1979_04 |
|---|
