2,5-Dimethoxytetrahydrofuran → Cohrhuugbltlpt-uhfffaoysa-
反応式
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].CO[CH:13]1[CH2:17][CH2:16][CH:15](OC)O1>C(O)(=O)C>[N:2]1([CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:13]=[CH:17][CH:16]=[CH:15]1参加物
4
実験手順
Ethyl 4-aminobutanoate hydrochloride (0.2 mole) is added to 300 ml glacial acetic acid containing (0.3 mole) sodium acetate. The mixture is heated until the solution becomes clear and then 2,5-dimethoxy tetrahydrofuran (about 0.2 mole) is added as quickly as possible. The solution is refluxed for an additional two minutes and the acetic acid is flash evaporated. The residue is distilled to give ethyl 4-(1-pyrryl)butanoate. The acid is obtained by hydrolyzing the ester in alcoholic sodium hydroxide followed by neutralization with hydrochloric acid.
後処理
- temperatureThe mixture is heated until the solution
- temperatureThe solution is refluxed for an additional two minutes
- customevaporated
- distillationThe residue is distilled
出典と根拠
- ORDレコード
- ord-67af0670350c41ddae1a6c6c1d9fb593
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04148998
反応ノート
読み込み中…