C([O-])(=O)C.[Na+].Cl.[S:7]([CH:11]([NH2:15])[C:12]([OH:14])=[O:13])([OH:10])(=[O:9])=[O:8].CO[CH:18]1[CH2:22][CH2:21][CH:20](OC)O1>C(O)(=O)C.C(OC(=O)C)C>[S:7]([CH:11]([N:15]1[CH:18]=[CH:22][CH:21]=[CH:20]1)[C:12]([OH:14])=[O:13])([OH:10])(=[O:9])=[O:8]To a solution of sodium acetate (0.1 mole) in about 300 ml of glacial acetic acid is added about 0.05 mole of α-sulfo-α-aminoacetic acid hydrochloride. The solution is heated to reflux for 5 minutes, 2,5-dimethoxytetrahydrofuran (1 equivalent based on α-sulfo-α-aminoacetic acid hydrochloride) is added as quickly as possible, and the solution refluxed for an additional 2 minutes. The acetic acid is flash evaporated leaving a residue which is taken up in ethylacetate. The ethyl acetate is filtered, dried and evaporated to give α-sulfo-α-(1-pyrryl) acetic acid.
読み込み中…
