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Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxetane | HCID 10423 | — |
| 反応物 | N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide | HCID 21444211 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide | HCID 23347568 | — |
反応手順
A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04156693 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-f2c120316ee347cb8ea232a7c1248f59 |
| 出典メモ | uspto-grants-1979_05 |