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(1-Isopropylpiperidin-4-yl)methanamine → 2-Chloropropane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-Isopropylpiperidin-4-yl)methanamine | HCID 7258859 | — |
| 反応物 | 3-Chloro-6-chlorocarbonylphenylsulfenyl chloride | HCID 10728826 | — |
| 生成物 | 2-Chloropropane | HCID 6361 | — |
| 生成物 | N-(piperidin-4-ylmethyl)acetamide | HCID 4341747 | — |
反応手順
2-(1-sopropylpiperid-4-ylmethyl)-6-chloro-1,2-benzisothiazolin-3-one is obtained analogously to Example 33 by reacting 3-chloro-6-chlorocarbonylphenylsulfenyl chloride and 1-isopropyl-4-aminomethylpiperidine [boiling point 15 :95°-97° C.; obtained from 4-acetylaminomethylpiperidine and isopropyl chloride analogously to Singh et al., J. Med. Chem. 12, 949 (1969) and Werbel et al., supra]. After recrystallization in acetone, yellow crystals of melting point 134°-135° C. are obtained; yield: 37% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04156729 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-96feb2b4c82e4f69ac86803b109e0cef |
| 出典メモ | uspto-grants-1979_05 |