化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 2-Chloromethyl-3-ethoxypyridine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (3-Ethoxypyridin-2-yl)methanol | HCID 22018715 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Chloromethyl-3-ethoxypyridine hydrochloride | HCID 20474185 | — |
反応手順
Thionyl chloride (8 cc) was added over 8 minutes to a stirred solution of 3-ethoxy-2-hydroxymethylpyridine (5.6 g) in chloroform (60 cc) at room temperature. After 11/2 hrs the mixture was evaporated to dryness and the residue was recrystallised from 0.16 M ethanolic hydrogen chloride/diethyl ether (1:1) to give 2-chloromethyl-3-ethoxypyridine hydrochloride (6.5 g) m.p. 176°-179.5°. (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04156727 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-0572a0990f034a81beadd8005107c15c |
| 出典メモ | uspto-grants-1979_05 |