化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyl isocyanate → N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl isocyanate | HCID 62412 | — |
| 反応物 | Propanenitrile, 2-amino- | HCID 411840 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea | HCID 21316847 | — |
反応手順
To a stirring solution of 21.1 g (0.3 mole) 2-aminopropionitrile in 300 ml. dry tetrahydrofuran under a nitrogen atmosphere, there is added 30.7 g (0.3 mole) t-butyl isocyanate (97%). The resulting mixture is heated at reflux for five hours. At the end of this period, the tetrahydrofuran is removed at reduced pressure. The solid is recrystallized from methanol:water, 60:40, to give N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea, m.p. 161°-3°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04156738 |
| 出典データセット | uspto-grants-1979_05 |
| ORD ID | ord-f6408094509d48d58ea659d4a8ff15bc |
| 出典メモ | uspto-grants-1979_05 |