tert-Butyl isocyanate → N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea

HRID 263265

反応式

HRID 263265 の反応式
[NH2:1][CH:2]([CH3:5])[C:3]#[N:4].[C:6]([N:10]=[C:11]=[O:12])([CH3:9])([CH3:8])[CH3:7]>O1CCCC1>[C:3]([CH:2]([NH:1][C:11]([NH:10][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:12])[CH3:5])#[N:4]

参加物

4

反応物 2

HCID 62412tert-Butyl isocyanateHCID 411840Propanenitrile, 2-amino-

生成物 1

HCID 21316847N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirring solution of 21.1 g (0.3 mole) 2-aminopropionitrile in 300 ml. dry tetrahydrofuran under a nitrogen atmosphere, there is added 30.7 g (0.3 mole) t-butyl isocyanate (97%). The resulting mixture is heated at reflux for five hours. At the end of this period, the tetrahydrofuran is removed at reduced pressure. The solid is recrystallized from methanol:water, 60:40, to give N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea, m.p. 161°-3°.

後処理

  1. temperatureThe resulting mixture is heated
  2. temperatureat reflux for five hours
  3. customAt the end of this period, the tetrahydrofuran is removed at reduced pressure
  4. customThe solid is recrystallized from methanol

出典と根拠

ORDレコード
ord-f6408094509d48d58ea659d4a8ff15bc
出典データセット
uspto-grants-1979_05
特許番号
US04156738

関連ノート

読み込み中…