Isopropanol → 3-(4-Chloro-3-sulfamoylbenzoyl)-1,2-dimethylindole

HRID 263296

反応式

HRID 263296 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[CH3:15][N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]1[CH3:25].[Cl-].[Al+3].[Cl-].[Cl-].C(O)(C)C>ClC(Cl)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([C:18]2[C:19]3[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:16]([CH3:15])[C:17]=2[CH3:25])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

参加物

6

反応物 4

HCID 3776IsopropanolHCID 134081,2-DimethylindoleHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 213166383-(4-Chloro-3-sulfamoylbenzoyl)-1,2-dimethylindole

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

is obtained as described in Example 10 (a) from 10 g 4-chloro-3-sulfamoylbenzoyl chloride and 6.53 g 1,2-dimethylindole in dichloro-ethane in the presence of 12 g aluminum chloride. After treatment with isopropanol, crystals having a melting point of 247°-249° C. are obtained.

後処理

  1. customis obtained
  2. customare obtained

出典と根拠

ORDレコード
ord-a3b045773a7b453484155875cccb118d
出典データセット
uspto-grants-1979_05
特許番号
US04156732

関連ノート

読み込み中…