関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Biphenyl | HCID 7095 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 3-Methylpentanoyl chloride | HCID 12648279 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Nitrobenzene | HCID 7416 | — |
| 生成物 | (+)-4-(3'-Methylpentanoyl)biphenyl | HCID 21322796 | — |
反応手順
To commercially available biphenyl (0.08 mole) and anhydrous aluminium trichloride (0.1 mole) dissolved in dry nitrobenzene (90ml), (+)-3-methylpentanoylchloride (0.1mole) the preparation of which is known and described in United Kingdom Patent Application No. 36211/75), is added in drops, the temperature being maintained at about -7° C. during the addition. The mixture is then stirred for about 18 hr. with cooling in an ice bath. It is then poured onto a mixture of ice, water and concentrated hydrochloric acid and stirred for 0.5 hr., and the nitrobenzene layer is separated. The nitrobenzene is removed by steam distillation and the residue is crystallised from a small volume of ethanol to constant melting point.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04149413 |
|---|
| 出典データセット | uspto-grants-1979_04 |
|---|
| ORD ID | ord-d8bd9553888746338d44dceea6760389 |
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| 出典メモ | uspto-grants-1979_04 |
|---|
