Hydrochloric Acid → 5-Chloro-3-(1-methyl-4-piperidyloxy)-1,2-benzisoxazole hydrochloride
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][N:8]=[C:7]([O:10][CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)[C:6]=2[CH:18]=1.Cl>C(O)C.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][N:8]=[C:7]([O:10][CH:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]3)[C:6]=2[CH:18]=1参加物
5
実験手順
A solution of 2.20 g (8.24 mmole) of 5-chloro-3-(1-methyl-4-piperidyloxy)-1,2-benzisoxazole (prepared as described in Example 11) in 20 ml of ethanol was cooled to 5° C. 2.5 ml of a 4N solution of hydrogen chloride in dioxane were added dropwise to the cooled solution, and the resulting mixture was stirred at room temperature for 30 minutes. At the end of this time, the solvent was removed from the reaction mixture by distillation under reduced pressure. The solid residue thus obtained was recrystallized from ethanol to afford 2.47 g (yield 98.7%) of the title compound as colorless curd-like crystals, melting at 212°-214° C. (with decomposition).