2',4'-Dihydroxyacetophenone → 1-[4-(3-Chloropropoxy)-2-hydroxyphenyl]-1-ethanone

HRID 263463

反応式

HRID 263463 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].Br[CH2:13][CH2:14][CH2:15][Cl:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:16][CH2:15][CH2:14][CH2:13][O:8][C:6]1[CH:5]=[CH:4][C:3]([C:9](=[O:11])[CH3:10])=[C:2]([OH:1])[CH:7]=1

参加物

5

反応物 3

HCID 69902',4'-DihydroxyacetophenoneHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

生成物 1

HCID 17146611-[4-(3-Chloropropoxy)-2-hydroxyphenyl]-1-ethanone収率 87%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

10 g (66 mmole) of 2',4'-dihydroxyacetophenone, 10 ml (101 mmole) of 1-bromo-3-chloropropane and 22.7 g (164 mmole) of anhydrous potassium carbonate in 250 ml of acetone were mixed and refluxed under heating for 16 hours. The mixture was cooled to room temperature, the solid insoluble was separated by filtration, and the filtrate was evaporated to dryness. The residue was dispersed in ethyl ether, filtered and dried to give 13.1 g (87%) of the product, melting point 74° C.

後処理

  1. temperaturerefluxed
  2. temperatureunder heating for 16 hours
  3. customthe solid insoluble was separated by filtration
  4. customthe filtrate was evaporated to dryness
  5. additionThe residue was dispersed in ethyl ether
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-6ddbaf6bf6ee49f2989f825a5856d3a5
出典データセット
uspto-grants-1997_07
特許番号
US05643927

関連ノート

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