HCID 22860484、化合物 → Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-

HRID 263473ノート

反応式

HRID 263473 の反応式
C([O:5][C:6](=[O:14])[C@H:7]([CH3:13])[CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])(C)(C)C>Cl.O1CCOCC1>[CH3:13][C@H:7]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[C:6]([OH:14])=[O:5]

参加物

3

反応物 1

HCID 22860484HCID 22860484、化合物

生成物 1

HCID 15814191Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-収率 71.9%

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

To 2.68 g of 2(S)-methyl-3-(methylsulfonyl)propionic acid t-butyl ester was added 20 mL of 4N hydrochloric acid/dioxane and the mixture stirred at room temperature for 19 hours. The solvent was removed in vacuo to afford 2.18 g of crude product, which was recrystallized from ethyl acetate/hexane to yield 1.44 g of 2(S)-methyl-3-(methylsulfonyl)-propionic acid as white crystals: ##STR75##

後処理

  1. customThe solvent was removed in vacuo
  2. customto afford 2.18 g of crude product, which
  3. customwas recrystallized from ethyl acetate/hexane

出典と根拠

ORDレコード
ord-f1b03014ce944e579a6b6d3b8f39b779
出典データセット
uspto-grants-1997_07
特許番号
US05643924

反応ノート

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