1,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butane → 1,4-Bis[4-[(1-hydroxyureido)methyl]phenoxy]butane

HRID 263537

反応式

HRID 263537 の反応式
C([O:8][N:9]([CH2:13][C:14]1[CH:44]=[CH:43][C:17]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]([O:35]CC3C=CC=CC=3)[C:32]([NH2:34])=[O:33])=[CH:26][CH:25]=2)=[CH:16][CH:15]=1)[C:10]([NH2:12])=[O:11])C1C=CC=CC=1.[H][H]>CN(C)C=O.C(O)C.[C].[Pd]>[OH:35][N:31]([CH2:30][C:27]1[CH:28]=[CH:29][C:24]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][O:18][C:17]2[CH:43]=[CH:44][C:14]([CH2:13][N:9]([OH:8])[C:10]([NH2:12])=[O:11])=[CH:15][CH:16]=2)=[CH:25][CH:26]=1)[C:32]([NH2:34])=[O:33]

参加物

5

反応物 2

HCID 542130111,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butaneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 542604191,4-Bis[4-[(1-hydroxyureido)methyl]phenoxy]butane収率 62%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 19794673N,N-dimethylformamide ethanol溶媒

実験手順

1,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butane (1.94 g) was dissolved in 45 ml of dimethylformamide-ethanol (8:1), mixed with 0.29 g of 10% palladium carbon and then the mixture was stirred for 22 hours at room temperature in an atmosphere of hydrogen. The catalyst was removed by filtration using Celite, and the solvent was evaporated under a reduced pressure to obtain 0.84 g of 1,4-bis[4-[(1-hydroxyureido)methyl]phenoxy]butane.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under a reduced pressure

出典と根拠

ORDレコード
ord-0864f6c93e4148b1b8946b1cc0b66e5f
出典データセット
uspto-grants-1997_07
特許番号
US05643931

関連ノート

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