Triethylamine → 4-Ethyl-3-o-chlorobenzoyl-4-oxazolin-2-one

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:11]([C:13]1[NH:14][C:15](=[O:18])[O:16][CH:17]=1)[CH3:12].C(N(CC)CC)C>C1C=CC=CC=1>[CH2:11]([C:13]1[N:14]([C:4](=[O:5])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[Cl:1])[C:15](=[O:18])[O:16][CH:17]=1)[CH3:12]

参加物

実験手順

A solution of o-chlorobenzoyl chloride (1.93 g.) and 4-ethyl-4-oxazolin-2-one (1.13 g.) in 30 ml. of benzene is cooled to 10° C. and reacted with 1.21 g. of triethylamine dissolved in 5 ml. of benzene. The reaction mixture is stirred at room temperature for 1 hour. The excess triethylamine and benzene is removed under reduced pressure to leave a light yellow oil (2.4 g.) which is triturated with ethanol whereupon a crystalline solid separates. The solid is removed and washed with a small amount of cold ethanol and dried. Yield 0.3 g.; m.p. 110°-112° C.