3-(4-Methoxyphenyl)-2-methylpropanoic acid → 6-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

HRID 263614

反応式

HRID 263614 の反応式
[CH3:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=O>O>[CH3:14][O:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH:2]([CH3:1])[C:3]2=[O:5])=[CH:8][CH:9]=1

参加物

3

反応物 1

HCID 105358043-(4-Methoxyphenyl)-2-methylpropanoic acid

生成物 1

HCID 2311786-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

α-Methyl-β-(ρ-methoxyphenyl)propionic acid (15 g.) is added to polyphosphoric acid (170 g.) at 50° C. and the mixture is heated at 83°-90° for two hours. The syrup is poured into iced water, stirred for one-half hour, and then extracted with ether three times. The ether solution is washed with water twice, and with 5% NaHCO3 five times until all the acidic material has been removed. The remaining neutral solution is washed with water and dried over sodium sulfate. Evaporation of the solution gives the indanone as a pale yellow oil.

後処理

  1. temperaturethe mixture is heated at 83°-90° for two hours
  2. extractionextracted with ether three times
  3. washThe ether solution is washed with water twice
  4. customwith 5% NaHCO3 five times until all the acidic material has been removed
  5. washThe remaining neutral solution is washed with water
  6. dry with materialdried over sodium sulfate
  7. customEvaporation of the solution

出典と根拠

ORDレコード
ord-9b0f8e4202e347eaae7a999e1675d815
出典データセット
uspto-grants-1997_07
特許番号
US05643959

関連ノート

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