CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid

HRID 263632

反応式

HRID 263632 の反応式
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

参加物

4

反応物 1

HCID 367964CID 367964

生成物 1

HCID 154877913-(4-Fluorophenyl)-2-methylpropanoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To ρ-fluoro-α-methylcinnamic acid (177.9 g., 0.987 mole) in 3.6 l. ethanol is added 11.0 g. of 5% Pd/C and the mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i. Uptake is 31/32 lbs. (97% of theoretical). After filtering the catalyst, the filtrate is concentrated in vacuo to give the product ρ-fluoro-α-methylhydrocinnamic acid used without weighing in next step.

後処理

  1. customis reduced at room temperature under a hydrogen
  2. filtrationAfter filtering the catalyst
  3. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-d11b9a6d66034ab5bd512ecc437e9c4c
出典データセット
uspto-grants-1997_07
特許番号
US05643959

関連ノート

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