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Phthalic Anhydride → 2-(8-Chloro-2-methylquinolin-5-yl)-1H-isoindole-1,3(2H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phthalic Anhydride | HCID 6811 | — |
| 反応物 | 1,2,3-Trichlorobenzene | HCID 6895 | — |
| 反応物 | 8-Chloro-2-methylquinolin-5-amine | HCID 21322927 | — |
| 生成物 | 2-(8-Chloro-2-methylquinolin-5-yl)-1H-isoindole-1,3(2H)-dione | HCID 21322916 | 83.3% |
反応手順
95 g of trichlorobenzene was added to 23.3 g (0.12 mole) of 8-chloro-5-amino-quinaldine and 18.0 g (0.12 mole) of phthalic anhydride, and the mixture was reacted under reflux for 2 hours at the boiling point. After cooling, the precipitated crystals were separated by filtration, and dried to afford 32 g (0.10 mole) of 8-chloro-5-phthalimidoquinaldine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04150025 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-6b48f7d1232f46a9947bdd586f8143d2 |
| 出典メモ | uspto-grants-1979_04 |