Water → 3-Oxo-2-(2,4,6-trimethyl-phenyl)-propionitrile
反応式
C[O-].[Na+].[CH:4](OCC)=[O:5].[CH3:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[C:11]=1[CH2:18][C:19]#[N:20].O>C1C=CC=CC=1>[CH:4]([CH:18]([C:11]1[C:12]([CH3:17])=[CH:13][C:14]([CH3:16])=[CH:15][C:10]=1[CH3:9])[C:19]#[N:20])=[O:5]参加物
6
実験手順
To a stirred mixture of sodium methoxide (2.78 g, 51 mmol) and ethyl formate (4.0 g, 54 mmol) in 100 mL of benzene was added 2,4,6 trimethylphenylacetonitrile (8.0 g, 50 mmol) over 5 min. After stirring for an additional hour it was treated with water (100 mL) and the layers were separated. The aqueous layer was separated and acidified with 10% HCl and extracted with ethyl acetate. After drying the solvent was removed in vacuo to afford a-formyl-2,4,6-trimethylphenylacetonitrile as colorless crystals melting at 120°-122° C.
後処理
- customthe layers were separated
- customThe aqueous layer was separated
- extractionextracted with ethyl acetate
- customAfter drying the solvent
- customwas removed in vacuo
出典と根拠
- ORDレコード
- ord-51083602d49a4444b155fca3f57b2e95
- 出典データセット
- uspto-grants-1997_07
- 特許番号
- US05644057
反応ノート
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