Phosgene → (3R)-oxolan-3-yl carbonochloridate

HRID 263791

反応式

HRID 263791 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[OH:5][C@@H:6]1[CH2:10][CH2:9][O:8][CH2:7]1>C1(C)C=CC=CC=1>[O:8]1[CH2:9][CH2:10][C@@H:6]([O:5][C:1]([Cl:4])=[O:2])[CH2:7]1

参加物

4

反応物 2

HCID 6371Phosgene2 回HCID 641512(-)-3-Hydroxytetrahydrofuran

生成物 1

HCID 58089797(3R)-oxolan-3-yl carbonochloridate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

12.5 ml (24.15 mmol) of a 20% solution of phosgene in toluene are cooled in an ice-bath, a solution of 1.06 g (12.03 mmol) of (R)-(+)-3-hydroxytetrahydrofuran (JPS CHIMIE, Bevaix, Switzerland) in a small amount of toluene is then added dropwise and, after the mixture has been stirred at RT for 2 h, the excess phosgene is expelled with argon. After concentration by evaporation in a rotary evaporator under reduced pressure, the crude title compound is further processed without being further purified.

後処理

  1. concentrationAfter concentration
  2. customby evaporation
  3. customin a rotary evaporator under reduced pressure

出典と根拠

ORDレコード
ord-3e81419723974c258315e77cfbce1753
出典データセット
uspto-grants-1997_07
特許番号
US05643878

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