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4-(Dimethylamino)butyric acid hydrochloride → 4-(Dimethylamino)butanoyl chloride hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Dimethylamino)butyric acid hydrochloride | HCID 12691640 | — |
| 溶媒 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 4-(Dimethylamino)butanoyl chloride hydrochloride | HCID 19037478 | — |
反応手順
10 g (60 mmol) of 4-dimethylaminobutyric acid hydrochloride (Janssen; Bruggen/Germany) are heated for approximately 3 h at 65° C. in 30 ml of SOCl2. SOCl2 is evaporated off and the residue is stirred to yield the title compound: TLC of a sample dissolved in methanol, Rf (U)=0.67; TLC of 4-dimethylaminobutyric acid hydrochloride, Rf (U)=0.50.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05643878 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-41aced89796c40338464e2b8252692e6 |
| 出典メモ | uspto-grants-1997_07 |