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Phosphorus pentachloride → Pyridine-3-sulfonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | 3-Pyridinesulfonic acid | HCID 69468 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Pyridine-3-sulfonyl chloride | HCID 3164136 | — |
反応手順
3-pyridylsulfonic acid 5-5 (30 g, 0.188 mole) was added to PCl5 (46.8 g, 0.225 mole) suspended in 150 mL toluene and heated to reflux ovemight. The suspension was cooled and concentrated to yield a yellow oil, which was diluted with benzene, filtered through a pad of celite and concentrated to give 5-6 as a yellow oil that was used in the next step without purification. 1H NMR (300 MHz, CDCl3) a 9.27 (1H, s), 8.98 (1H, d, 8.35 (1H, d), 7.62 (1H, dd).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05646000 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-02b5186211584d53996df20fcf1dd224 |
| 出典メモ | uspto-grants-1997_07 |