Hydrochloric Acid → (S)-2-amino-3-phenylpropan-1-ol hydrochloride

HRID 263847ノート

反応式

HRID 263847 の反応式
C(OC([NH:8]C(C1C=CC=CC=1)(O)CC)=O)(C)(C)C.[ClH:19].[C:20]1([CH3:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[O:27]1CCO[CH2:29][CH2:28]1>>[ClH:19].[NH2:8][C@@H:29]([CH2:26][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:28][OH:27]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 312751,4-DioxaneHCID 77504178Tert-butoxycarbonylamino-1-phenyl-propan-1-ol

生成物 1

HCID 69017766(S)-2-amino-3-phenylpropan-1-ol hydrochloride

実験手順

A solution of 20.10 g (80.00 mmol) of (S)-2-(tert-butoxycarbonylamino-1-phenyl-propan-1-ol [J. Med. Chem. 33, 2707 (1990)] in 200 ml of a 4N solution of gaseous hydrogen chloride in anhydrous dioxane is stirred at room temperature for 30 min. After that, 60 ml of toluene are added and the mixture is concentrated in vacuo. This procedure is repeated a further two times and the residue is then triturated with a little ether, filtered off with suction and dried under high vacuum over KOH. 14.14 g (94% of theory) of the title compound are obtained as colourless crystals.

後処理

  1. concentrationthe mixture is concentrated in vacuo
  2. customthe residue is then triturated with a little ether
  3. filtrationfiltered off with suction
  4. dry with materialdried under high vacuum over KOH

出典と根拠

ORDレコード
ord-ab4decc95fcb469fbf128d77222c7e65
出典データセット
uspto-grants-1997_07
特許番号
US05646121

反応ノート

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